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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Trends Biochem Sci. 2018 Mar 12;43(5):380–394. doi: 10.1016/j.tibs.2018.02.009

Figure 4.

Figure 4

Substrate quality in biological context. (A) Higher quality substrates (i.e. those that are more efficiently phosphorylated by a kinase) are phosphorylated rapidly and to higher stoichiometry even at lower kinase activity. (B) Varying quality of mTOR substrates rationalizes their differential sensitivity to the mTORC1 inhibitor rapamycin. (C) Increasing CDK activity during the cell cycle contributes to the timing of substrate phosphorylation, with high quality substrates phosphorylated early (in G1/S phase) and lower quality substrates phosphorylated late (in G2/M phase).