Figure 1.

Morbidity of mice treated with anti-western equine encephalitis virus (WEEV) monoclonal antibodies following WEEV exposure. (A) Cohorts of 10 mice were administered 200 µg/mouse of ToR68-2E9 (purple), ToR68-2C3 (blue), ToR69-3A2 (green), Tor68-3G2 (orange), irrelevant anti-Marburg virus (100 µg/mouse; solid red) mAb per mouse or an equivalent volume of PBS (dashed red) mAb i.p. 24 h prior to aerosol exposure to WEEV Fleming (10³ PFU). Mice were weighed daily, and the percent weight loss was determined by comparison to pre-challenge day weights. (B) Clinical observations were made twice daily. Mice were moribund when displaying neurological signs of disease or were unresponsive to stimulus. Data shown are the clinical signs observed on Day 4 (average survival day) post-exposure.