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. 2018 Mar 27;10(4):152. doi: 10.3390/v10040152

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Identification of ellagic acid and gallic acid as the most active components of R. rosea against EBOV infection. (a) Twenty known R. rosea components were tested against pseudotyped EBOV infection at 12.5 μM; (b) Ellagic acid and (c) gallic acid were examined against HIV/EBOV (∆, red) and HIV/MARV (□, blue) infection in A549 cells in vitro for dose-response evaluation; (d) Cell viability assay of ellagic acid and gallic acid in A549 cells. Data are means ± SD (n = 3) from three independent experiments. The IC₅₀/CC₅₀ Values, 95% confidence intervals and selectivity indices for ellagic acid and gallic acid are listed in Supplementary Materials Table S1.