Figure 1.

Structure of the enterovirus 71 (EV71) genome. The highly structured 5′ UTR and 3′ UTR followed by the poly (A) tail control the viral protein translation by binding to the viral VPg protein. This is followed by proteolytic cleavage, and the original protein is matured into four structural proteins, VP1–VP4, and seven non-structural proteins, 2A–2C and 3A–3D.