Table 1.
Detection of varicella-zoster virus DNA in human intestine biopsies.
| Patient ID | Gender 1 | Age 2 | Disease at Time of Intestinal Biopsy | DNA 3 | |
|---|---|---|---|---|---|
| HSV-1 | VZV | ||||
| 1 | F | 72 | Small intestine B-cell lymphoma | – | 2 |
| 2 | F | 55 | Small intestine neuroendocrine tumor | – | 107 |
| 3 | F | 53 | Colonic adenocarcinoma | – | – |
| 4 | F | 57 | Small intestine B-cell lymphoma | – | – |
| 5 | F | 51 | Pancreatic carcinoma | – | – |
| 6 | M | 44 | Small intestine gastrointestinal stromal tumor | – | – |
| 7 | F | 40 | Colonic adenocarcinoma | – | – |
| 8 | F | 65 | Bladder adenocarcinoma | – | – |
| 9 | M | 48 | Metastatic melanoma | – | – |
| 10 | M | 61 | Small intestine neuroendocrine tumor | – | – |
| 11 | F | 64 | Ovarian papillary serous carcinoma | – | 423 |
| 12 | F | 60 | Colonic adenocarcinoma | – | – |
| 13 | M | 58 | Small intestine neuroendocrine tumor | – | – |
| 14 | M | 55 | Small intestine neuroendocrine tumor | – | – |
| 15 | M | 73 | Metastatic carcinoma (unknown origin) | – | – |
| 16 | F | 75 | Adnexal carcinosarcoma | – | 93 |
| 17 | M | 32 | Peutz-Jeghers syndrome | – | 30 |
| 18 | M | 68 | Carcinoid small intestine | – | – |
1 F, Female; M, male; 2 Age in years; 3 Frozen human intestine biopsies were analyzed for presence of herpes simplex virus type 1 (HSV-1) and varicella-zoster virus (VZV) DNA by quantitative real-time PCR (qPCR). Viral genome copies per 100,000 human cells are indicated. –, undetectable by qPCR. Human genomic DNA was readily detected in all samples, as determined by qPCR for the human single copy gene hydroxymethylbilane synthase [HMBS, average (±SEM) Ct-value = 25.4 (±0.23)].