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Peptides mimicking/targeting the complex CD4bs. (Left) Structure-based design of a CD4bs mimetic peptide (bottom) based on the crystal structure of a gp120-CD4 complex (top, pdb 1rzj). Fragments corresponding to the CD4bs are shown in red, yellow and green, respectively, and the CDR2-like loop of CD4 contacting gp120 is in blue. (Right) General design of antibody paratope mimetic peptides (top) and specifically for b12 (bottom) based on the b12-gp120 crystal structure (pdb 2ny7).
