Figure 3.

CD4⁺ cells were preserved in the blood of CO as compared with FIV cats at 2 weeks (P = 0.0492), and approached preservation at 4 weeks (P = 0.0612) FIV PI. At 2 and 4 weeks FIV PI, control SHAM cats had higher CD4⁺ cells than FIV cats (P = 0.002 and P < 0.0001, respectively), and CO cats (2 weeks, P = 0.0090; 4 weeks, P = 0.0034) (A). Naïve CD4⁺CD45RA⁺ cells were also preserved in the CO cats compared with FIV cats at 2 weeks (P = 0.0012), but not at 4 weeks (P = 0.332) FIV PI. At 2 and 4 weeks FIV PI, SHAM CD4⁺CD45RA⁺ cells were greater than FIV cats (2 weeks, P = 0.0069; 4 weeks, P = 0.0012), yet the SHAM was only different than the CO cats at 4 weeks FIV-PI (P = 0.0062) CD4⁺ cells (B). Bars indicate statistical differences between the indicated groups. Significant differences were noted among the three groups over time (CD4⁺ cells, P = 0.0004; CD4⁺CD45RA⁺ cells, P = 0.0012).