Table 1.
Predictors of ketamine response.
| Predictors of Ketamine Response | Studies | Number of Subjects | |
|---|---|---|---|
| Sociodemographic | None | None | None |
| Clinical | Positive family history of alcohol use disorder in a first-degree relative (FHP) | Phelps et al. 2009 [17]. | MDD (n = 26) |
| Luckenbaugh et al. 2012 [18]. | MDD and BD (n = 33) | ||
| Niciu et al. 2014 [19]. | MDD (n = 52) | ||
| High BMI | Niciu et al. 2014 [19]. | MDD (n = 108) | |
| No prior suicide history | Niciu et al. 2014 [19]. | MDD (n = 108) | |
| Peripheral biochemistry | Low baseline adiponectin levels | Machado-Vieira et al. 2017 [20]. | MDD (n = 49) BD (n = 31) |
| High baseline peripheral B12 level | Permoda-Osip et al. 2013 [21]. | BD (n = 20) | |
| Polysomnography | Low baseline delta sleep ratio | Duncan et al. 2013 [22]. | MDD (n = 30) |
| Neurochemistry | Low Glx/glutamate ratio | Salvadore et al. 2012 [23]. | MDD (n = 14) |
| Neuroimaging | Increased pretreatment anterior cingulate cortex activity | Salvadore et al. 2009 [24]. | MDD (n = 11) HC (n = 11) |
| Genetics | Val66Met BDNF allele | Laje et al. 2012 [25]. | MDD (n = 62) |
| Cognition | Poor baseline neurocognitive score | Murrough et al. 2013 [26]. | MDD (n = 25) |