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. 2018 Apr 27;8:6636. doi: 10.1038/s41598-018-25084-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of excess strain load-priming on osteocytes’ SCLEROSTIN expression at 35 and 60% tibia length. 20 months old female mice in group 4 received two bouts of 11 N loading and sacrificed two days thereafter. Representative transverse DAPI and SCLEROSTIN-immunostained images with the percentage changes of SCLEROSTIN-positive osteocytes in non-loaded contralateral control and loaded right tibia demonstrating significant reduction in percentage of SCLEROSTIN-positive osteocytes at 35% of tibia length only. 8 sections from 4 mice per group were quantified. Box-plots represent means ± SEM. Group sizes were n = 4. *denotes p < 0.05.