. Author manuscript; available in PMC: 2018 Aug 25.

Published in final edited form as: Genet Med. 2017 Oct 12;20(7):708–716. doi: 10.1038/gim.2017.167

Table 3.

Urea metabolism and total urinary nitrogen excretion in healthy volunteers after a 3 day adaptation period to sodium phenylbutyrate (NaPB arm), sodium benzoate (NaBz arm) or a combination of both drugs (Mix arm)

	NaPB	MIX	NaBz	P <
N intake, g/d	9.81 (0.56)	9.81 (0.56)	9.81 (0.56)	-
Plasma urea, AUC_0-8 (mmol/L)	23.6 (2.2)	26.3 (2.3)	25.5 (3.1)	0.16
Urea production, μmol•kg⁻¹•h⁻¹	192 (14)	200 (15)	197 (26)	0.80
Urinary N, g/d	6.47 (0.54)	6.81 (0.63)	6.38 (0.56)	0.67
% N excreted from daily intake	65.6 (3.6)	70.5 (6.5)	65.1 (4.6)	0.48
Urinary Urea N, g/d	4.16 (0.64)	4.69 (0.69)	4.20 (0.58)	0.74
Urea N as a % total urinary N	63.6 (6.7)	67.7 (5.6)	65.1 (5.3)	0.88
Urinary urea-¹⁵N, g/d	37.0 (4.9)	38.0 (3.8)	36.3 (5.0)	0.94
¹⁵N as % of test meal	15.2 (2.1)	15.5 (1.1)	14.7 (1.8)	0.93