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. 2018 Mar 21;9(4):174. doi: 10.3390/genes9040174

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Regulation by miR-181. miR-181 inhibits the translation of Serine Palmitoyltransferase Long Chain Base Subunit 1 (SPTLC1), tripartite motif-containing 2 (TRIM2), silent mating type information regulation 2 homolog 1 (SIRT1), BTB Domain Containing 3 (BTBD3), high-mobility group protein 1 (HMGB1), B-cell lymphoma 2 (Bcl2), Nicotinamide phosphoribosyltransferase (NAMPT), methyl CpG binding protein 2 (MeCP2), and X-linked inhibitor of apoptosis (XIAP). The decreased levels of miR-181 in AD brain are denoted by the red arrow. The green arrows denote the hypothetical upregulation of the targeted proteins and their cellular effects.