Table 1.

Tumor Necrosis Factor Receptor-associated Protein 1 (TRAP1) is either positively or negatively selected in different tumors. Depending on the tumor type, TRAP1 expression is increased in the tumor compared to the normal tissues and further increases during progression and in metastatic sites or is lost in the later stages of the disease.

Tumor Type	TRAP1 Expression	References
Bladder Cancer	Inversely correlated with tumor stage	Yoshida et al. [16]
Breast Cancer	High in tumor cells compared to surrounding normal tissue	Zhang et al. [29] Maddalena et al. [32]
Clear Cell Renal Cell Carcinoma	Inversely correlated with tumor stage	Yoshida et al. [16]
Cervical Cancer	Inversely correlated with tumor stage	Yoshida et al. [16]
Colorectal Carcinoma	High in tumor cells compared to surrounding healthy mucosa, increased in advanced pathological stage, positively correlated with worse survival, upregulated at the transition between low- and high-grade adenomas	Costantino et al. [33], Pak et al. [34] Maddalena et al. [35]
Glioblastoma	High in tumor cells compared to adjacent normal astrocytes	Siegelin et al. [36]
Lung Cancer	High in tumor cells compared to adjacent normal bronchial mucosa	Im et al. [37]
Ovarian Cancer	Inversely correlated with stage and grade, positively correlated with better survival, reduced in peritoneal deposit distant from primary site	Aust et al. [24] Matassa et al. [26] Walker et al. [38] Amoroso et al. [39]
Prostate Cancer	High in both localized and metastatic prostate cancers compared to normal prostate or benign prostatic hyperplasia	Leav et al. [40] Lisanti et al. [41]