Figure 3.

Wnt signaling pathway regulates deiodinases. Wnt ligand binds to the receptor, Frizzled (FZD), and the co-receptor, lipoprotein receptor-related protein 5 or 6 (Lpr5/6). Disheveled (Dvl) is then recruited, leading to phosphorylation of Lrp5/6 by casein kinase 1 (CK1) and glycogen-synthase kinase 3β (GSK-3β). Axin then binds, allowing for β-catenin to accumulate and translocate to the nucleus to activate transcription of D3. D3 levels then increase and lead to inactivation of T4 to reverse triiodothyronine (rT3) and T3 to T2.