Table 2.
Completers
|
Intent-to-treat group
|
||||||
---|---|---|---|---|---|---|---|
Variable | Time point | UCa Mean (SD) | CCTb Mean (SD) | Cohen’s d* | UC Mean (SD) | CCT Mean (SD) | Cohen’s d* |
Primary outcomes | |||||||
Reaction time | Baseline | 94.74 | 93.18 | 94.73 | 93.79 | ||
(10.57) | (10.46) | (10.97) | (10.88) | ||||
T2 | 95.72 | 99.98 | 0.58 | 95.73 | 99.29 | 0.43 | |
(10.20) | (9.78) | (10.60) | (10.29) | ||||
T3 | 95.63 | 99.91 | 0.58 | 95.63 | 99.61 | 0.47 | |
(10.57) | (9.53) | (10.97) | (10.08) | ||||
Processing speed | Baseline | 95.34 | 104.32 | 95.37 | 103.60 | ||
(14.67) | (14.75) | (14.56) | (14.65) | ||||
T2 | 101.55 | 108.61 | 0.14 | 101.57 | 106.61 | 0.23 | |
(14.67) | (13.74) | (14.57) | (13.81) | ||||
T3 | 103.17 | 109.25 | 0.20 | 103.20 | 109.14 | 0.16 | |
(14.91) | (13.56) | (14.80) | (13.42) | ||||
Simple attention | Baseline | 96.25 | 100.18 | 96.21 | 100.66 | ||
(12.94) | (12.97) | (12.73) | (12.76) | ||||
T2 | 100.65 | 99.44 | 0.40 | 100.62 | 98.73 | 0.50 | |
(13.01) | (12.78) | (12.80) | (12.61) | ||||
T3 | 99.29 | 103.11 | 0.01 | 99.28 | 102.42 | 0.10 | |
(12.89) | (12.42) | (12.69) | (12.55) | ||||
Motor speed | Baseline | 94.03 | 98.49 | 93.99 | 98.34 | ||
(14.04) | (14.02) | (14.11) | (14.09) | ||||
T2 | 96.64 | 102.31 | 0.09 | 96.60 | 102.00 | 0.08 | |
(13.80) | (12.77) | (13.87) | (12.97) | ||||
T3 | 99.80 | 101.15 | 0.24 | 99.76 | 101.35 | 0.21 | |
(13.80) | (12.27) | (13.87) | (12.53) | ||||
Secondary outcomes | |||||||
Verbal memory | Baseline | 93.91 | 98.65 | 93.88 | 98.34 | ||
(13.53) | (13.53) | (13.22) | (13.21) | ||||
T2 | 103.11 | 96.62 | 0.85 | 103.08 | 95.78 | 0.90 | |
(13.53) | (13.12) | (13.22) | (12.88) | ||||
T3 | 98.91 | 101.58 | 0.15 | 98.88 | 100.51 | 0.22 | |
(13.53) | (12.98) | (13.22) | (12.76) | ||||
Visual memory | Baseline | 95.32 | 103.53 | 95.22 | 102.20 | ||
(13.77) | (13.77) | (14.68) | (14.67) | ||||
T2 | 97.32 | 95.92 | 0.71 | 97.22 | 95.68 | 0.60 | |
(13.77) | (13.26) | (14.68) | (14.10) | ||||
T3 | 96.20 | 103.52 | 0.07 | 96.09 | 101.60 | 0.10 | |
(13.77) | (13.09) | (14.68) | (13.92 | ||||
Cognitive flexibility | Baseline | 98.20 | 98.93 | 98.17 | 98.65 | ||
(10.58) | (10.43) | (11.59) | (11.40) | ||||
T2 | 102.55 | 104.29 | 0.10 | 102.45 | 103.28 | 0.03 | |
(10.02) | (9.92) | (10.84) | (10.80) | ||||
T3 | 100.35 | 105.21 | 0.41 | 100.32 | 103.77 | 0.27 | |
(10.58) | (9.82) | (11.59) | (10.69) | ||||
Self-reported cognitive | Baseline | 5.99 | 4.78 | 5.98 | 4.59 | ||
(4.91) | (4.91) | (4.73) | (4.73) | ||||
impairment (PAOFI)c,d | T2 | 3.24 | 2.47 | 0.09 | 3.23 | 2.40 | 0.12 |
(4.91) | (4.61) | (4.73) | (4.41) | ||||
T3 | 4.94 | 2.83 | 0.19 | 4.93 | 2.78 | 0.17 | |
(4.91) | (4.48) | (4.73) | (4.38) | ||||
Neurobehavioral | Baseline | 61.61 | 64.14 | 61.59 | 63.65 | ||
(15.45) | (15.46) | (15.00) | (15.01) | ||||
symptoms (FrSBe)d,e | T2 | 55.76 | 55.98 | 0.16 | 55.74 | 56.31 | 0.11 |
(15.45) | (14.12) | (15.00) | (13.58) | ||||
T3 | 57.76 | 54.70 | 0.39 | 57.74 | 55.19 | 0.33 | |
(15.45) | (13.57) | (15.00) | (13.42) | ||||
Quality of life (FACT-P)f | Baseline | 102.56 | 106.32 | 102.61 | 106.68 | ||
(21.44) | (21.44) | (21.28) | (21.30) | ||||
T2 | 104.37 | 107.38 | 0.04 | 104.42 | 106.80 | 0.09 | |
(21.44) | (19.19) | (21.28) | (18.59) | ||||
T3 | 101.51 | 105.39 | 0.01 | 101.56 | 104.65 | 0.05 | |
(21.44) | (18.30) | (21.28) | (18.59) |
Non-italicized effect sizes favor CCT over UC, italicized effect sizes favor UC over CCT.
UC=Usual Care;
CCT=Computerized Cognitive Training;
PAOFI=Patient Assessment of Own Functioning Inventory;
Higher score indicates worse function;
Frontal Systems Behavior Scale;
FACT-P=Functional Assessment of Cancer Therapy-Prostate