Table 2.

Least squares means and between-within effect sizes by group from Baseline to T2 and Baseline to T3.

		Completers			Intent-to-treat group
Variable	Time point	UCa Mean (SD)	CCTb Mean (SD)	Cohen’s d*	UC Mean (SD)	CCT Mean (SD)	Cohen’s d*
Primary outcomes
Reaction time	Baseline	94.74	93.18		94.73	93.79
		(10.57)	(10.46)		(10.97)	(10.88)
	T2	95.72	99.98	0.58	95.73	99.29	0.43
		(10.20)	(9.78)		(10.60)	(10.29)
	T3	95.63	99.91	0.58	95.63	99.61	0.47
		(10.57)	(9.53)		(10.97)	(10.08)
Processing speed	Baseline	95.34	104.32		95.37	103.60
		(14.67)	(14.75)		(14.56)	(14.65)
	T2	101.55	108.61	0.14	101.57	106.61	0.23
		(14.67)	(13.74)		(14.57)	(13.81)
	T3	103.17	109.25	0.20	103.20	109.14	0.16
		(14.91)	(13.56)		(14.80)	(13.42)
Simple attention	Baseline	96.25	100.18		96.21	100.66
		(12.94)	(12.97)		(12.73)	(12.76)
	T2	100.65	99.44	0.40	100.62	98.73	0.50
		(13.01)	(12.78)		(12.80)	(12.61)
	T3	99.29	103.11	0.01	99.28	102.42	0.10
		(12.89)	(12.42)		(12.69)	(12.55)
Motor speed	Baseline	94.03	98.49		93.99	98.34
		(14.04)	(14.02)		(14.11)	(14.09)
	T2	96.64	102.31	0.09	96.60	102.00	0.08
		(13.80)	(12.77)		(13.87)	(12.97)
	T3	99.80	101.15	0.24	99.76	101.35	0.21
		(13.80)	(12.27)		(13.87)	(12.53)
Secondary outcomes
Verbal memory	Baseline	93.91	98.65		93.88	98.34
		(13.53)	(13.53)		(13.22)	(13.21)
	T2	103.11	96.62	0.85	103.08	95.78	0.90
		(13.53)	(13.12)		(13.22)	(12.88)
	T3	98.91	101.58	0.15	98.88	100.51	0.22
		(13.53)	(12.98)		(13.22)	(12.76)
Visual memory	Baseline	95.32	103.53		95.22	102.20
		(13.77)	(13.77)		(14.68)	(14.67)
	T2	97.32	95.92	0.71	97.22	95.68	0.60
		(13.77)	(13.26)		(14.68)	(14.10)
	T3	96.20	103.52	0.07	96.09	101.60	0.10
		(13.77)	(13.09)		(14.68)	(13.92
Cognitive flexibility	Baseline	98.20	98.93		98.17	98.65
		(10.58)	(10.43)		(11.59)	(11.40)
	T2	102.55	104.29	0.10	102.45	103.28	0.03
		(10.02)	(9.92)		(10.84)	(10.80)
	T3	100.35	105.21	0.41	100.32	103.77	0.27
		(10.58)	(9.82)		(11.59)	(10.69)
Self-reported cognitive	Baseline	5.99	4.78		5.98	4.59
		(4.91)	(4.91)		(4.73)	(4.73)
impairment (PAOFI)c,d	T2	3.24	2.47	0.09	3.23	2.40	0.12
		(4.91)	(4.61)		(4.73)	(4.41)
	T3	4.94	2.83	0.19	4.93	2.78	0.17
		(4.91)	(4.48)		(4.73)	(4.38)
Neurobehavioral	Baseline	61.61	64.14		61.59	63.65
		(15.45)	(15.46)		(15.00)	(15.01)
symptoms (FrSBe)d,e	T2	55.76	55.98	0.16	55.74	56.31	0.11
		(15.45)	(14.12)		(15.00)	(13.58)
	T3	57.76	54.70	0.39	57.74	55.19	0.33
		(15.45)	(13.57)		(15.00)	(13.42)
Quality of life (FACT-P)f	Baseline	102.56	106.32		102.61	106.68
		(21.44)	(21.44)		(21.28)	(21.30)
	T2	104.37	107.38	0.04	104.42	106.80	0.09
		(21.44)	(19.19)		(21.28)	(18.59)
	T3	101.51	105.39	0.01	101.56	104.65	0.05
		(21.44)	(18.30)		(21.28)	(18.59)

^*Non-italicized effect sizes favor CCT over UC, italicized effect sizes favor UC over CCT.

^aUC=Usual Care;

^bCCT=Computerized Cognitive Training;

^cPAOFI=Patient Assessment of Own Functioning Inventory;

^dHigher score indicates worse function;

^eFrontal Systems Behavior Scale;

^fFACT-P=Functional Assessment of Cancer Therapy-Prostate