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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Mucosal Immunol. 2017 Nov 1;11(2):562–574. doi: 10.1038/mi.2017.74

Figure 4. NOX1 population frequencies and genetic variation.

Figure 4

(a) Allele frequency of NOX1 p.D360N in different populations according to Exome Aggregation Consortium (ExAC) data and published literature.13 (b) Number of hemizygotes found for a given variant (missense, nonsense, frameshift) in NOX2 and NOX1 is blotted according to amino acid position (X-axis). Frequency is based on ExAC data. (c) Probability of loss of-function intolerance (pLI) of 727 human X-chromosomal genes based on ExAC data. X-linked primary immunodeficieny genes and NOX1 gene are highlighted.