Table 2.
Population genetics of p.D360N variant
| Gender | Ancestry | Group | N | MAF (%) | p-value Cases vs. controls |
OR |
|---|---|---|---|---|---|---|
| Male | European | Control | 4744 | 2.66 | ||
|
| ||||||
| IBD | 5549 | 2.74 | 0.843 | 1.03 | ||
| UC | 2462 | 3.45 | 0.068 | 1.31 | ||
| CD | 2895 | 2.18 | 0.217 | 0.82 | ||
|
| ||||||
| Ashkenazi Jewish13 | Control | 1708 | 0.82 | |||
|
| ||||||
| UC | 297 | 3.37 | 1.25 × 10−3 | 4.22 | ||
|
| ||||||
| Female | European | Control | 4769 | 2.44 | ||
|
| ||||||
| IBD | 5587 | 2.77 | 0.149 | 1.14 | ||
| UC | 2263 | 3.05 | 0.041 | 1.26 | ||
| CD | 3138 | 2.50 | 0.857 | 1.02 | ||
|
| ||||||
| Ashkenazi Jewish13 | Control | 906 | 0.99 | |||
|
| ||||||
| UC | 262 | 1.53 | 0.343 | 1.55 | ||
MAF, minor allele frequency; OR, odds ratio. P-values were determined by the ALLELIC test or Fisher’s exact method13.