Table 1.

Clinical, Biochemical, and Parathyroid Disease Characteristics in Patients Undergoing Initial Parathyroidectomy for Primary Hyperparathyroidism

Variable	Family history of PHPT, n = 205	Sporadic PHPT, n = 452	p Value
Age, y, mean ± SD	42.8 ± 17.6	59.2 ± 13.5	< 0.001
Age ≤ 45 years, n (%)	113 (55.1)	55 (12.1)	< 0.001
Male sex, n (%)	80 (39)	95 (21)	< 0.001
Race/ethnicity, n (%)
Caucasian	182 (88.8)	368 (81.4)	0.09
Asian	5 (2.4)	23 (5.1)
African American	16 (7.8)	42 (9.3)
Hispanic	1 (0.5)	15 (3.3)
Multiracial	1 (0.5)	3 (0.6)
Preoperative laboratory value, mean ± SD
Total Ca, mmol/L	2.8 ± 0.26	2.77 ± 0.199	0.65
Intact PTH, pg/mL	145 ± 151	136 ± 113	0.96
No. of patients with >1 enlarged parathyroid gland, n (%)
Multiple gland disease	144 (70.2)	65 (14.4)	< 0.001
Parathyroid carcinoma, n (%)	5 (2.4)	0 (0)	0.003
Follow-up, n (%)*
Biochemical cure	183 (89.2)	435 (96.2)	0.005

Biochemical cure was defined as normal calcium and PTH during follow up

^*At 2 years follow-up

PHPT, primary hyperparathyroidism; PTH, parathyroid hormone.