Table 1.

Effects of newly designed and synthesized molecules on TLR3 agonist-induced expression of innate immune genes in vitro.

Compds	%a
	ISG54	ISG56	IL-8	Groβ
(+)-JQ1	91	90	90	91
11	−62	−73	−61	−57
12	−114	−93	−86	−98
13	92	92	88	88
14	3.6	2.7	−1.0	5.7
15	−9.0	−17	−5.0	−12
16	61	64	60	61
19	94	94	88	82
22	22	21	48	48
23	99	99	98	98
26	57	56	53	56
27	−21	−29	−32	−37
28	95	95	94	94
29	29	32	56	52
30	92	92	48	48
33	20	20	–b	–
34	85	85	81	81
35	93	93	99	99

^aConcentration of compounds: 10 μM. Inhibitory rates (%) are reported as the geometric mean derived from three independent measurements except where indicated.

^bNot tested.