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. Author manuscript; available in PMC: 2019 May 10.
Published in final edited form as: Eur J Med Chem. 2018 Apr 3;151:450–461. doi: 10.1016/j.ejmech.2018.04.006

Table 2.

IC50 values of selected compounds of inhibiting TLR3 agonist-induced expression of innate immune genes in hSAECs.

Compds IC50, μMa
ISG54 ISG56 IL-8 Groβ
(+)-JQ1 1.38 1.63 1.51 1.49
RVX-208 2.63 2.74 3.85 3.73
23 7.9 7.7 4.3 3.9
28 0.49 0.51 0.53 0.58
35 0.81 0.86 0.73 0.79
a

IC50 values are reported as the mean derived from three independent measurements. Each one is generated from at least 8 different concentrations.