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Pharmacokinetic parameters of compounds 28 and 35.a
| Compounds | 28 | 35 | |
|---|---|---|---|
| IV (10 mg/kg) |
t1/2b (h) | 1.2 | 0.83 |
| AUC0-tc (ng·h/mL) | 14,700 | 11,400 | |
| VSSd (L/kg) | 0.864 | 1.125 | |
| CLe (mL/min/kg) | 11.5 | 14.7 | |
|
| |||
| PO (20 mg/kg) |
Cmaxf (ng/mL) | 80 | 36 |
| AUC0-t (ng·h/mL) | 450 | 104 | |
Compounds were formulated in 10% DMSO/60% PEG-400/30% Saline.
half-life.
Exposure over test time.
Volume of distribution at steady state.
Total clearance.
Maximum plasma concentration.
