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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Neurobiol Aging. 2018 Feb 19;66:68–74. doi: 10.1016/j.neurobiolaging.2017.11.017

Table 2.

Cross-sectional association between IGF-1, IGFBP-3, IGF-1/IGFBP-3 and gait speed and cognition among cognitively unimpaired MCSA participants aged 50-95 by sex

Total IGF-1 IGFBP-3 IGF-1/IGFBP-3
N B (95% CI) p N B (95% CI) p N B (95% CI) p
Men
Z Gait speed 699 701 699
 Tertile 1 Reference Reference Reference
 Tertile 2 0.09 (−0.06, 0.24) 0.219 0.06 (−0.09, 0.20) 0.461 0.15 (−0.03, 0.33) 0.094
 Tertile 3 0.04 (−0.11, 0.19) 0.597 0.11 (−0.06, 0.27) 0.196 0.04 (−0.13, 0.21) 0.627
Z Memory 699 701 699
 Tertile 1 Reference Reference Reference
 Tertile 2 0.15 (−0.01, 0.30) 0.068 −0.03 (−0.19, 0.13) 0.700 0.05 (−0.14, 0.24) 0.620
 Tertile 3 0.05 (−0.11, 0.20) 0.568 −0.09 (−0.27, 0.08) 0.278 0.11 (−0.07, 0.29) 0.244
Z Attention 682 684 682
 Tertile 1 Reference Reference Reference
 Tertile 2 −0.006 (−0.13, 0.12) 0.931 −0.08 (−0.20, 0.05) 0.247 0.002 (−0.15, 0.16) 0.978
 Tertile 3 −0.02 (−0.15, 0.11) 0.747 −0.02 (−0.16, 0.12) 0.736 0.004 (−0.14, 0.15) 0.957
Z Language 689 691 689
 Tertile 1 Reference Reference Reference
 Tertile 2 0.10 (−0.04, 0.23) 0.150 −0.07 (−0.20, 0.07) 0.343 0.07 (−0.10, 0.23) 0.411
 Tertile 3 0.01 (−0.12, 0.15) 0.842 −0.06 (−0.21, 0.09) 0.409 0.07 (−0.09, 0.23) 0.372
Z Visuospatial 679 681 679
 Tertile 1 Reference Reference Reference
 Tertile 2 −0.02 (−0.17, 0.13) 0.792 −0.04 (−0.19, 0.11) 0.593 0.04 (−0.14, 0.23) 0.640
 Tertile 3 0.05 (−0.10, 0.20) 0.528 0.11 (−0.06, 0.27) 0.207 −0.02 (−0.19, 0.16) 0.841
Z Global 673 675 673
 Tertile 1 Reference Reference Reference
 Tertile 2 0.06 (−0.07, 0.19) 0.346 −0.08 (−0.20, 0.05) 0.240 0.05 (−0.11, 0.20) 0.541
 Tertile 3 0.03 (−0.10, 0.16) 0.683 −0.04 (−0.18, 0.10) 0.608 0.05 (−0.10, 0.20) 0.495
Women Total IGF-1 IGFBP-3 IGF-1/IGFBP-3
N B (95% CI) p N B (95% CI) p N B (95% CI) p
Z Gait speed 616 618 616
 Tertile 1 Reference Reference Reference
 Tertile 2 0.12 (−0.04, 0.29) 0.151 0.14 (−0.03, 0.31) 0.104 −0.004 (−0.16, 0.15) 0.959
 Tertile 3 0.17 (−0.001, 0.34) 0.051 0.15 (−0.02, 0.32) 0.084 0.08 (−0.12, 0.28) 0.413
Z Memory 616 618 616
 Tertile 1 Reference Reference Reference
 Tertile 2 0.11 (−0.07, 0.29) 0.234 0.11 (−0.07, 0.30) 0.216 −0.06 (−0.22, 0.11) 0.489
 Tertile 3 0.06 (−0.12, 0.25) 0.504 0.12 (−0.07, 0.31) 0.218 −0.11 (−0.33, 0.10) 0.308
Z Attention 611 613 611
 Tertile 1 Reference Reference Reference
 Tertile 2 0.27 (0.13, 0.41) <0.001 0.16 (0.02, 0.30) 0.028 0.11 (−0.02, 0.24) 0.097
 Tertile 3 0.15 (0.005, 0.30) 0.042 0.08 (−0.06, 0.23) 0.263 −0.03 (−0.20, 0.14) 0.736
Z Language 612 614 612
 Tertile 1 Reference Reference Reference
 Tertile 2 0.11 (−0.04, 0.26) 0.164 0.04 (−0.11, 0.19) 0.626 −0.06 (−0.20, 0.08) 0.393
 Tertile 3 0.08 (−0.07, 0.23) 0.302 0.15 (−0.004, 0.31) 0.056 −0.08 (−0.26, 0.09) 0.356
Z Visuospatial 607 609 607
 Tertile 1 Reference Reference Reference
 Tertile 2 0.30 (0.13, 0.47) <0.001 0.21 (0.05, 0.38) 0.013 0.07 (−0.09, 0.22) 0.400
 Tertile 3 0.25 (0.08, 0.43) 0.004 0.18 (0.003, 0.35) 0.046 0.09 (−0.11, 0.29) 0.371
Z Global 602 604
 Tertile 1 Reference Reference Reference
 Tertile 2 0.23 (0.09, 0.38) 0.002 0.16 (0.009, 0.30) 0.037 0.01 (−0.12, 0.14) 0.865
 Tertile 3 0.16 (0.007, 0.31) 0.041 0.16 (0.01, 0.31) 0.034 −0.05 (−0.22, 0.13) 0.594

Models adjusted for age, education, body mass index, and the Charlson comorbidity index score.