TABLE 2.
Significant Relationships on Univariate Analysis and Multivariate Cox Regression Analysis for Recurrence Free and Overall Survival
| Univariate Analysis
| |||||
|---|---|---|---|---|---|
| RFS
|
OS
|
||||
| N | Median Survival (mo) | p value | Median Survival (mo) | p value | |
| LN Status | 0.004 | 0.011 | |||
| Negative | 136 | 17.3 | 24.3 | ||
| Positive | 81 | 13.7 | 17.6 | ||
| Age | 0.044 | 0.008 | |||
| <60 yrs | 72 | 20.1 | 27.8 | ||
| ≥60 yrs | 176 | 15.0 | 18.2 | ||
| Grade | 0.022 | 0.081 | |||
| Well Diff. | 43 | 20.0 | 27.8 | ||
| Mod Diff. | 132 | 16.0 | 19.3 | ||
| Poorly Diff. | 53 | 12.5 | 22.2 | ||
| Undifferentiated | 1 | – | 4.8 | ||
| Multivariate Analysis
| ||||
|---|---|---|---|---|
| RFS
|
RFS
|
OS
|
OS
|
|
| p | aHR (95% CI) | p | aHR (95% CI) | |
| Adjuvant Therapy | 0.005 | 0.55 (0.37-0.84) | 0.013 | 0.58 (0.38-0.89) |
| LN Positive | 0.001 | 2.06 (1.39-3.04) | 0.002 | 1.95 (1.28-2.95) |
| Age (Increasing) | 0.005 | 1.02 (1.01-1.04) | 0.011 | 1.02 (1.01-1.04) |
| ASA Status (Higher*) | 0.003 | 0.54 (0.37-0.81) | 0.073 | 0.69 (0.46-1.04) |
| Grade (vs. Well Diff.) | ||||
| Mod Diff. | 0.597 | 1.13 (0.72-1.76) | 0.573 | 1.14 (0.72-1.80) |
| Poorly Diff. | 0.015 | 1.89 (1.13-3.16) | 0.166 | 1.44 (0.86-2.43) |
| Undifferentiated | 0.025 | 10.53 (1.34-82.74) | 0.029 | 9.97 (1.26-78.94) |
Abbreviations: RFS, recurrence free survival; OS, overall survival; N, number at risk; mo, months; LN, lymph node; R status, resection status; yrs, years; Mod, moderately; Diff., differentiated; aHR, adjusted hazard ratio; ASA, American Society of Anesthesiologists classification system.
*
ASA Higher signifies ASA class of 3 or greater