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. Author manuscript; available in PMC: 2018 Apr 29.
Published in final edited form as: Cell Stem Cell. 2016 Aug 11;19(3):326–340. doi: 10.1016/j.stem.2016.07.002

Figure 4. CDKAL1−/−, KCNQ1−/− and KCNJ11−/− cells show defective glucose stimulated insulin secretion and impaired ability to maintain glucose homeostasis after transplantation into streptozotocin-treated immunodeficient mice.

Figure 4

(A) human insulin GSIS at 2 weeks after transplantation of the mutant cells compared to wildtype cells (wt). (B) GSIS secretion of SCID-beige mice carrying human cells at 6 weeks after transplantation. p values calculated by one-way repeated measures ANOVA. (C and D) Intraperitoneal glucose tolerance test (IPGTT) (C) and area under the curve (AUC) (D) of STZ treated mice 6 weeks after transplantation. p values calculated by two-way repeated measures ANOVA with a Bonferroni test for multiple comparisons between wt and mutant cells. n=8 mice for each condition. hESCs were differentiated using protocol 2. n.s. indicates a non-significant difference. p values were *p<0.05 and ** p<0.01, *** p<0.001, **** p<0.0001. See also Figure S4.