. Author manuscript; available in PMC: 2019 Feb 21.

Published in final edited form as: ACS Chem Neurosci. 2017 Nov 2;9(2):306–319. doi: 10.1021/acschemneuro.7b00329

Table 3.

NAB-14 has minimal off-target effects at ligand-gated ion channels.

receptor	% control response (20 μM NAB-14)	N	p-value
GluA1	101 ± 2.8	9	0.997
GluA2	101 ± 1.9	5	0.999
GluK2	101 ± 3.2	10	0.954
GluK2/GluK4	101 ± 1.9	5	0.999
GluK2/GluK5	96.5 ± 4.6	4	0.999
α4β2-nACh	97.3 ± 3.9	3	0.999
α7-nACh	89.6 ± 4.2	6	0.584
α1β2γδ-nACh	100 ± 3.3	4	0.999
5-HT3A	94.5 ± 4.5	7	0.999
α1β2γ2-GABAA	107 ± 2.8	6	0.998
ρ-GABAA	96.6 ± 0.8	5	0.999
α1-Glycine	103 ± 2.2	6	0.999
P2X²	93.1 ± 1.6	5	0.662

The control current responses to agonist and the responses to agonist with 20 μM NAB-14 [% control response (mean ± s.e.m.)] for all groups were compared by one-way ANOVA [F(13,84) = 2.054, p = 0.028]. Post hoc Bonferroni tests compared the control and 20 μM NAB-14 groups for each receptor type.