Table 1.
Motor behavioral assays.
| Behavior at 8 months of age | Mean (SEM) Wildtype$ | Mean (SEM) Pinkl −/− Baseline | Mean (SEM) Pinkl −/− Levodopa |
|---|---|---|---|
| Challenge Beam (Whole) | 2.12 (0.14) | 3.666 (0.611) | 3.217 (0.423) |
| Challenge Beam (Last 1/3) | 1.491 (0.059) | 2.373 (0.685) | 1.688 (0.262) |
| # Foot faults | 0.46 (0.12) | 0.667 (0.349) | 0.429 (0.14) |
| Hindlimb Steps | 18.92 (2.41) | 29.143 (5.045) | 22.857 (3.384) |
| Forelimb Steps | 21.5 (1.73) | 53 (9.859) | 31 (5.282) |
| Gait (steps 1-2 forelimb R) | Not tested | 13.133 (0.986) | 14.533 (1.041) |
| Gait (steps 2-3 forelimb R) | Not tested | 10.917 (1.058) | 15.825 (1.023) |
| Gait (steps 1-2 hindlimb R) | Not tested | 13.55 (1.056) | 14.386 (0.559) |
| Gait (steps 2-3 hindlimb R) | Not tested | 10.8 (2.064) | 16.043 (0.775) |
| # Calls | Not tested | 120 (15.74) | 126.143 (19.202) |
| Call Rate | Not tested | 1.33 (0.175) | 1.402 (0.123) |
| Complex Calls (%) | 62.23 (3.65) | 58 (5.29) | 4 5.7 (5.13) |
| Average FM Duration | 0.043 (0.0021) | 0.0484 (0.00413) | 0.0596 (0.00766) |
| Average FM Bandwidth | 21496 (1185.6) | 17377.46 (875.938) | 18823.92 (454.33) |
| Average FM Intensity | −44.675 (0.5025) | −54.101 (0.566) | −56.179 (0.626) |
| Average Peak FM Frequency | 55494 (911.83) | 54832.25 (597.588) | 52007.7 (351.216) |
Means (SEM) for limb motor and vocal motor variables for Pink1 −/− animals at baseline and after administration of levodopa. Wildtype data is provided as a comparison. *Non-transformed data,
$
Data extracted from Grant et al., 2015.