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Effect of Tph treatment (10 mg/kg/day for one month) on tight junction proteins and Aβ transport proteins in microvessels isolated from 5XFAD mice brain. (a) Representative blots and densitometry analysis of claudin-5 and ZO-1. (b) Representative blots and densitometry analysis of P-gp and LRP1. Data are presented as mean ± SEM of five mice in each group. **P<0.01, ***P<0.001.
