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EC50 values, fold change and potency of hit compounds obtained from primary and secondary screening that showed significant enhancement in the barrier intactness of bEnd3 monolayer.
| Compound | Pharmacological activity# | EC50 (μM) | Fold ↓ in Pc | Potency |
|---|---|---|---|---|
| BrG | Activator of cGMP-dependent protein kinases | 4.9 | 0.14 | 0.03 |
| JW74 | Inhibitor of canonical Wnt signaling | 3.6 | 0.27 | 0.08 |
| Phen | Metalloprotease inhibitor | 0.4 | 0.15 | 0.38 |
| SB2 | GSK-3β inhibitor | 12.8 | 0.43 | 0.03 |
| Tph | Potent antioxidant | 2.4 | 0.37 | 0.15 |
