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. 2018 Apr 30;9(5):478. doi: 10.1038/s41419-018-0528-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a The percentage of Tim-3⁺ CD8 T cells in the infiltrated CD8 T cells was determined by flow cytometry. The percentages of Tim-3⁺ CD8 T cells in the tumor-infiltrating CD8 T cells (TIL-T) and peripheral blood CD8 T cells of HCC patients (PBL-T) and healthy controls (PBL-C) was analyzed. n = 25 for each group. b The protein-coding potential and the ORF size (a two-exon gene) of long non-coding RNA Lnc-Tim3 (ENST00000443947.1) were analyzed by databases. c Relatively increased levels of Lnc-Tim3 were confirmed in tumor-infiltrating CD8 T cells (TIL-T) by comparing them with those in the peripheral blood CD8 T cells of HCC patients (PBL-T) and healthy controls (PBL-C). n = 40 for each group. d The Pearson’s correlation of Lnc-Tim3 expression and the percentage of IFN-γ⁺ CD8 T cells in the tumor-infiltrating CD8 T cells was analyzed. (n = 25). Data are presented as means ± S.E.M. (*P < 0.05)