Table 1.
Univariate and multivariate analyses of risk factors associated with overall survival and disease-free survival of HCC patients in training cohort
| Variables | Overall Survival | Disease-free survival | |||||||
|---|---|---|---|---|---|---|---|---|---|
| n | Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
| HR(95% CI) | P | HR(95% CI) | P | HR(95% CI) | P | HR(95% CI) | P | ||
| Sex | |||||||||
| Male | 58 | 1 | 0.433 | NA | 1 | 0.385 | NA | ||
| Female | 9 | 0.689(0.271–1.751) | 0.685(0.292–1.609) | ||||||
| Age, years | |||||||||
| ≤60 | 53 | 1 | 0.574 | NA | 1 | 0.321 | NA | ||
| >60 | 14 | 1.226(0.603–2.494) | 1.389(0.725–2.660) | ||||||
| HBV | |||||||||
| Negative | 8 | 1 | 0.040 | 1 | NS | 1 | 0.216 | NA | |
| Positive | 59 | 4.443(1.072–18.414) | 2.588(0.589–11.017) | 1.716(0.729–4.041) | |||||
| Liver cirrhosis | |||||||||
| Absence | 8 | 1 | 0.051 | NA | 1 | 0.454 | NA | ||
| Presence | 59 | 4.128(0.996–17.105) | 1.386(0.590–3.259) | ||||||
| Tumor size, cm | |||||||||
| ≤5 cm | 47 | 1 | <0.001 | 1 | 0.003 | 1 | 0.004 | 1 | 0.042 |
| >5 cm | 20 | 3.432(1.833–6.426) | 2.919(1.443–5.903) | 2.383(1.320–4.302) | 1.934(1.024–3.655) | ||||
| AFP, ng/ml | |||||||||
| <20 | 27 | 1 | 0.646 | NA | 1 | 0.634 | NA | ||
| ≥20 | 40 | 1.153(0.625–2.125) | 1.146(0.653–2.013) | ||||||
| Capsulation formation formation formation | |||||||||
| Absence | 31 | 1 | 0.162 | NA | 1 | 0.055 | NA | ||
| Presence | 36 | 0.652(0.357–1.188) | 0.582(0.335–1.012) | ||||||
| Microvascular invasion | |||||||||
| Presence | 12 | 1 | <0.001 | 1 | NS | 1 | <0.001 | 1 | NS |
| Absence | 55 | 6.204(2.976–12.933) | 2.050(0.773–5.434) | 4.893(2.378–10.069) | 1.641(0.648–4.156) | ||||
| Edmondson-Steiner grade | |||||||||
| I & II | 43 | 1 | 0.001 | 1 | NS | 1 | <0.001 | 1 | 0.008 |
| III & IV | 24 | 2.731(1.487–5.015) | 2.117(0.967–4.634) | 3.235(1.809–5.785) | 2.423(1.262–4.652) | ||||
| BCLC stage | |||||||||
| 0 & A | 9 | 1 | 0.020 | 1 | 0.042 | 1 | 0.195 | NA | |
| B & C | 58 | 10.589(1.453–77.186) | 8.104(1.081–60.767) | 1.760(0.748–4.144) | |||||
| TNM stage | |||||||||
| Early (I & II) | 59 | 1 | 0.083 | NA | 1 | 0.549 | NA | ||
| Late (III & IV) | 8 | 1.876(0.921–3.822) | 1.247(0.606–2.566) | ||||||
| Rnd1 expression | |||||||||
| Low | 17 | 1 | 0.001 | 1 | 0.038 | 1 | <0.001 | 1 | 0.044 |
| High | 50 | 0.318(0.167–0.607) | 0.447(0.209–0.955) | 0.297(0.160–0.550) | 0.450(0.207–0.978) | ||||
HR hazard risk ratio, CI confidence interval, NA not applicable, NS not significant
*Significant results (P<0.05) are given in bold