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. 2018 Apr 23;9:425. doi: 10.3389/fphys.2018.00425

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Copyright © 2018 Zhang, Liu, Campbell and Wenk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic of the 2-state contraction model based on MyoSim. x₁ to x_n are different lengths of cross-bridges (n = 21 in the proposed FE model); x_ps is the cross-bridge length when the myosin head is bound to a directly opposed binding site; k₁ (x_i) and k₋₁ (x_i) are the strain-dependent rate constants for the attachment and detachment transitions, respectively.