Figure 3.

Neuroprotective effects of compounds (A) AntiOxBEN₁, 15 and 17 and (B) AntiOxBEN₂, 16 and 18 in human neuroblastoma SH-SY5Y cells against Aβ1–42 peptide-induced cytotoxicity measured by changes in cellular metabolic activity. Cells were pre-treated with mitochondriotropic antioxidants (10 μM) for 24 h before treatment with Aβ1–42 peptide (25 μM) for 48 h more. The comparisons were performed by using one-way ANOVA between the control (Aβ1–42 peptide) vs. preparation where antioxidants AntiOxBEN₁, AntiOxBEN₂ and 15–18 were pre-incubated. Data are means ± SEM of three independent experiments and the results are expressed as percentage of control (control = 100 %), which represents the cell density without any treatment in the respective time point. Significance was accepted with ^**P < 0.01 vs. control.