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. 2018 Apr 23;6:126. doi: 10.3389/fchem.2018.00126

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Copyright © 2018 Oliveira, Cagide, Teixeira, Amorim, Sequeira, Mesiti, Silva, Garrido, Remião, Vilar, Uriarte, Oliveira and Borges.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scheme 1 — Synthetic strategy followed to obtain derivatives 15–18 from benzoic acids 1–2. Reagents and conditions: a. POCl₃, NH₂(CH₂)₇CH₂OH or NH₂(CH₂)₉CH₂OH, DIPEA, DCM, r.t., 1–2 h; b. C₂Br₂Cl₄, diphos, THF, r.t., 20 h; c. PPh₃, 100°C, 48 h; d. BBr₃, anhydrous DCM, −70°C to r.t., 12 h.