Table 1.
Summary of biochemical assays on INMT from studies reviewed.
| INMT sequence alteration | Species | Substrate(s) reported | Km (μM) | Cell type | Publication |
|---|---|---|---|---|---|
| Reference | Human | Tryptamine | 850 | E. coli | Chu et al., 2015 |
| Uncertain | Rabbit | [14C-CH3]AdoMet + tryptamine | 852 | Lung homogenate | Chu et al., 2014 |
| Uncertain | Rabbit | [14C-CH3]AdoMet + tryptamine + DMT | 1,618 | Lung homogenate | Chu et al., 2014 |
| Reference | Rabbit | [14C-CH3]AdoMet + tryptamine | 430 | COS-1 | Thompson et al., 2001 |
| Trp138 | Rabbit | [14C-CH3]AdoMet + tryptamine | 3,500 | COS-1 | Thompson et al., 2001 |
| Pro202 | Rabbit | [14C-CH3]AdoMet + tryptamine | 1,270 | COS-1 | Thompson et al., 2001 |
| Reference | Rabbit | [14C-CH3]AdoMet + tryptamine | 270 | COS-1 | Thompson et al., 1999 |
| Val205/Glu219 | Human | [14C-CH3]AdoMet + tryptamine | 2,920 | COS-1 | Thompson et al., 1999 |
| Met205/Gly219 | Human | [14C-CH3]AdoMet + tryptamine | 2,920 | COS-1 | Thompson et al., 1999 |
| Uncertain | Human | Tryptamine | 430 | Lung homogenate | Räisänen and Kärkkäinen, 1978 |