Table 1.

SCN1B variants linked to human disease.

Disease	β1	β1B
Atrial fibrillation	R85H (Watanabe et al., 2009), D153N (Watanabe et al., 2009)	R85H (Watanabe et al., 2009), D153N (Watanabe et al., 2009)
Brugada syndrome	E87Q (Watanabe et al., 2008)	E87Q (Watanabe et al., 2008), H162P (Holst et al., 2012), W179X, R214Q (Holst et al., 2012; Hu et al., 2012)
Dravet syndrome	I106F (Ogiwara et al., 2012), Y119D (Ramadan et al., 2017), C121W (Wallace et al., 1998), R125C (Patino et al., 2009)	I106F (Ogiwara et al., 2012), Y119D (Ramadan et al., 2017),C121W (Wallace et al., 1998), R125C (Patino et al., 2009)
Generalized Epilepsy with Febrile Seizures Plus (GEFS+)	D25N (Orrico et al., 2009), R85H (Scheffer et al., 2006), R85C (Scheffer et al., 2006), R125L (Fendri-Kriaa et al., 2011), five amino acid deletions (IVS2-2A>C) (Audenaert et al., 2003)	D25N (Orrico et al., 2009), R85H (Scheffer et al., 2006), R85C (Scheffer et al., 2006), R125L (Fendri-Kriaa et al., 2011), five amino acid deletions (IVS2-2A>C) (Audenaert et al., 2003)
Idiopathic epilepsy		G257R (Patino et al., 2011)
Sudden Infant Death Syndrome (SIDS)		R214Q (Hu et al., 2012), R225C (Neubauer et al., in press)
Sudden Unexpected Nocturnal Death Syndrome (SUNDS)	V138I (Liu et al., 2014), T189M (Liu et al., 2014)	V138I (Liu et al., 2014)
Long QT Syndrome (LQTS)		P213T (Riuró et al., 2014)