Table 2.
Nav1.5 ID interacting proteins.
| Interacting protein | Effects on Nav1.5 | Reference(s) |
|---|---|---|
| Ankyrin-G (AnkG) | Proper expression at plasma membrane and coupling to actin cytoskeleton | Mohler et al., 2004 |
| Calmodulin (Cal) | Regulates biophysical properties | Tan et al., 2002; Kim et al., 2004; Young and Caldwell, 2005; Gabelli et al., 2014 |
| Ca2+/calmodulin-dependent protein kinase II (CaMKIIδ) | Phosphorylation and modulates excitability | Hund et al., 2010; Makara et al., 2014 |
| Fibroblast growth factor homologous factor 1B (FHF1B) | Modulate channel gating | Liu et al., 2003 |
| Nedd4-like-ubiqutin-protein ligases (Nedd4) | Ubiquitination and regulated internalization. Possible mechanism in modulation of channel density at the plasma membrane | Van Bemmelen et al., 2004; Rougier et al., 2005 |
| Synapse-associated protein 97 (SAP97) | Stability and anchoring to the cell membrane | Petitprez et al., 2011; Matsumoto et al., 2012 |