Table 4.
Monophasic and biphasic inactivation of NaV1.7, 1.3 and 1.6 in Ins1 cells
| Monophasic | Biphasic | |||||
|---|---|---|---|---|---|---|
| NaV current | V h (mV) | k | V h1 (mV) | k 1 | V h2 (mV) | k 2 |
| NaV1.3 | −79 ± 6 (8) | 9 ± 1 (8) | −87 ± 2 (26) | 9 ± 1 (26) | −55 ± 2 (26) | 7 ± 1 (26) |
| NaV1.6 | −73 ± 4 (10) | 8 ± 1 (10) | −86 ± 1 (25) | 8 ± 1 (25) | −56 ± 1 (25) | 6 ± 1 (25) |
| NaV1.7 | −94 ± 2 (38) | 9 ± 1 (38) | −97 ± 4 (9) | 8 ± 1 (9) | −67 ± 4 (9) | 10 ± 2 (9) |
Same data as in Table 1, except cells are divided between those that exhibited NaV current inactivation that were best described using a single Boltzmann function (monophasic) and those that were best described using a double Boltzmann function (biphasic) (Akaike information criterion test). Values represent means ± SEM of indicated number of cells (n). V h represents membrane potential at which inactivation is half‐maximal in cells with monophasic inactivation and k represents the slope factor. In cells with biphasic inactivation, V h1 and V h2 represent the membrane potential at which inactivation is half‐maximal for the current components inactivating at negative and positive membrane potentials, respectively. k 1 and k 2 represent the respective slope factors for the currents inactivating with V h1 and V h2.