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. 2018 Mar 23;596(9):1549–1574. doi: 10.1113/JP275478

Figure 13. Effects of benzbromarone on neurally evoked EJPs of (+/+) fundus muscles.

Figure 13

Responses to 1 Hz (arrow; left) and to 20 Hz (horizontal bars, right), 0.3 ms in duration for 1 s. A, under control conditions, prominent EFS evoked EJPs were followed by smaller, more slowly developing IJPs. B, l‐NNA (100 μm) inhibited IJPs and potentiated the amplitude of EJPs. C and D, benzbromarone (1–3 μm) caused a reduction in EFS evoked EJPs. E, EJPs were inhibited at a concentration of 5 μm. Benzbromarone also caused hyperpolarization in membrane potential. F, summary of the effects of benzbromarone on EJPs (1–20 Hz) and membrane potential (solid circles; n = 7; * P < 0.05; ** P < 0.01; *** P < 0.001, one‐way ANOVA).