Figure 4. Estimating ion channel densities from spiking pattern sequences.

Spiking patterns were determined for I _stim between 50 and 80 μA cm⁻², at 5 μA cm⁻² increments for two neurons labelled a and b on left. Planes are shown for only a subset of I _stim. To estimate the channel densities in neurons a and b, we determined all combinations of $\overline{g}$ _K,A and $\overline{g}$ _K,lt that could produce that sequence. The grey patches shown on each plane together demarcate the volume in which each arrow must exist. The spiking pattern sequence for neuron a leads to a more tightly constrained estimate of ion channel densities than does the sequence for neuron b.