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. 2018 Apr 9;115(17):E4091–E4100. doi: 10.1073/pnas.1714239115

Fig. 7.

Fig. 7.

Correlation analysis between the absolute values of the effect estimates of the brain regions, which were differentially responsive to viewing happy and sad faces across the treatment groups, an index of ambiguity in recognizing emotion corresponding to happy and sad faces, and the positive and negative affective states of individuals. The values of each outcome measure are illustrated on a white to dark-blue scale (with white indicating the lowest value and dark-blue indicating the highest value). Spearman’s rank-order correlation test was used; positive correlations (between the corresponding datasets) are indicated with a green arrow, and negative correlations are indicated with a red arrow. The scales of the negative and positive effects are (as expected) strongly anticorrelated with each other. A positive functional connectivity between the right insula and the right striatum (during emotional processing) is observed. (A) The differences in the neural processing of emotional input observed in the right amygdala and the right insula of the SCP group compared with the SCC group seem to (at least partially) reflect changes in their functional role (like monitoring ambiguity in recognizing facial expressions or the affective state) during the processing of emotional input. (B) The differences in neural processing of emotional input observed in the bilateral insula and the right orbitofrontal cortex of the PO group compared with the SCC group seem to (at least partially) reflect changes in their in-between functional connectivity during the processing of emotional input. %BOLD, absolute %BOLD signal change (compared with baseline) during exposure to the corresponding emotional face (happy and sad); LI/Lins, left insula; NEG.Aff., negative affect score; POS.Aff., positive affect score; RA/Ramy, right amygdala; Recg.Amb., index of recognition ambiguity when engaging with the corresponding emotional faces (happy and sad); RI/Rins, right insula; ROFC, right orbitofrontal cortex; RS, right striatum. *P < 0.1; **P < 0.01; ***P < 0.001.