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Inhibition of Slt by Bulgecin A. (A) The chemical structure of high-energy oxocarbenium species (shown in brackets), which is mimicked by bulgecine A. (B) Stereoview showing the Slt:bulgecin A complex superimposed with ligands 1p (orange) and 2p (gray) (as observed in the Slt:1p and the Slt:2p, respectively). Bulgecin A is represented in blue sticks. Residues interacting with the inhibitor are represented as capped sticks and labeled.
