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. 2018 Apr 12;2018:2021645. doi: 10.1155/2018/2021645

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Copyright © 2018 Paul K. Waltz et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

HO-2 is present within hepatocyte mitochondria under unstressed conditions. (a, b) Microscopy reveals localization of HO-2 within the mitochondria. Immunocytochemistry (a) demonstrates mitochondria (green; MitoTracker) and HO-2 (red) with areas of yellow representing colocalization. Immunoelectron microscopy demonstrates gold particle-labeled localization of HO-2 within hepatocyte mitochondria under normal cell culture conditions (b). (c, d) Western blot of mitochondrial fractions of untreated primary hepatocytes (c) and mouse liver (d) demonstrates HO-2 but not HO-1 expression protein levels under basal cell culture or without treatment. Mitochondrial cytochrome C oxidase subunit 4 (COX IV) is used as a mitochondrial loading control.