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. 2018 Apr 11;2018:1319272. doi: 10.1155/2018/1319272

Figure 1.

Figure 1

Constant high glucose, intermittent high glucose, and LPS individually induced a robust increase in the expression of TLR4 in THP-1 cells. (a) The mRNA levels of TLR4 were examined 24 h after the treatment of THP-1 cells. (b) The protein levels of TLR4 were examined 24 h after the treatment of THP-1 cells. NG, normal glucose (5 mM); M25, mannitol (25 mM); M5/25, intermittent mannitol (25–5 mM); HG, constant high glucose (25 mM); N/HG, intermittent glucose (25–5 mM). ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 versus ctrl, #p < 0.05, ##p < 0.01, ###p < 0.001 (n = 4 for each group).