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. 2018 Apr 15;2018:9108483. doi: 10.1155/2018/9108483

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Copyright © 2018 Ning He et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Generation of HO-1-haploinsufficient (HO-1^+/−) rats. (a) Schematic of the Hmox1 genetic locus and target site of TALENs. (b) Representative results of DNA sequencing from WT (+/+) and heterozygous rats (+/−). (c) Sequencing chromatograms showing the 11 bp deletion in the heterozygous (HO-1^+/−) sample. (d) Representative western blots (left) and statistical analysis (right) showing HO-1 expression in WT and HO-1^+/− livers under basal conditions (n = 8). The data represent the mean ± SD. ^∗∗ p < 0.01.