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. 2018 Apr 15;2018:9108483. doi: 10.1155/2018/9108483

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Copyright © 2018 Ning He et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Apoptosis failed to explain the protective role of HO-1 in HMP. (a) Identification of hepatocyte apoptosis was conducted on liver sections on day 7 in vivo and (b) at 6 h in vitro by the terminal dUTP nick-end labelling (TUNEL) assay (n = 6; scale bar: 200 μm), and the percentage of TUNEL-labelled nuclei was quantified. (c) Transcriptomic (qRT-PCR) analysis of caspase 3 and (d) Bcl-2/Bax in liver tissues from HO-1^+/− and WT (HO-1^+/+) rats on day 7 in vivo and at 6 h in vitro (n = 6). The data represent the mean ± SD.