Table 1.

Sampling design

Day	Dose	Sampling time
D7	1 mg kg−1 day−1	Pre‐dose
D14	2 mg kg−1day−1	Pre‐dose
D28 (Group 1) or D84 (Group 2)	3 mg−1kg−1day	Pre‐dose T1 hour T2 hour T4 hour T6 hour T9 hour (before the afternoon dosing)