Table 3.
Descriptive statistics of observed propranolol plasma concentrations (ng/mL)
| Group Number | Day | Theoretical time (h) | n | Geometric mean (CV %) | Median (range) |
|---|---|---|---|---|---|
| 1 | D7 | Predose | 10 | NA | 4.05 (0.780‐12.5) |
| D14 | Predose | 9 | NA | 8.46 (4.09‐15.8) | |
| D28 | Predose | 10 | 16.1 (75.5%) | 17.5 (4.73‐36.8) | |
| 1 | 10 | 62.9 (37.0%) | 62.2 (28.0‐112) | ||
| 2 | 10 | 66.0 (36.7%) | 61.8 (34.1‐119) | ||
| 4 | 10 | 47.4 (34.5%) | 47.0 (24.0‐75.5) | ||
| 6 | 10 | 44.4 (42.9%) | 37.2 (25.2‐87.3) | ||
| 9 | 10 | 31.7 (57.3%) | 33.8 (13.7‐71.4) | ||
| 2 | D7 | Predose | 11 | NA | 3.69 (1.13‐29.9) |
| D14 | Predose | 9 | NA | 5.86 (2.33‐25.5) | |
| D84 | Predose | 12 | 10.1 (113%) | 9.74 (1.72‐47.4) | |
| 1 | 10 | 37.7 (107%) | 41.9 (13.4‐104) | ||
| 2 | 11 | 60.5 (79.9%) | 74.3 (21.3‐125) | ||
| 4 | 12 | 40.3 (65.1%) | 44.2 (12.2‐124) | ||
| 6 | 11 | 33.3 (69.4%) | 31.4 (9.49‐112) | ||
| 9 | 12 | 23.4 (93.2%) | 21.7 (5.22‐108) |
NA, Not Applicable. Geometric mean and CV% were not calculated owing to a large range of sampling times.