Table 5.
Propranolol final model: parameter estimates
| Description of effects | Symbol | Estimate | 95% CI (RSE %) | CV% | |
|---|---|---|---|---|---|
| Fixed effects | Allometric effect of Weight on CL/F: θ1 × (WGT/median weight)0.75 | ||||
| CL/F | θ1 | 19.3 | 15.4‐23.2 (10.3%) | ||
| V/F | θ2 | 122 | 104‐140 (7.32%) | ||
| Ka | θ3 | 0.993 | 0.558‐1.43 (22.4%) | ||
| Random effects | |||||
| Between subjects’ variability | On CL/F | ω²1 | 0.195 | 0.0492‐0.341 (38.2%) | 44.2 |
| On Ka | ω²2 | 1.75 | 0.370‐3.13 (40.2%) | 132 | |
| Residual error | Proportional | σ²1 | 0.0953 | 0.0675‐0.123 (14.9%) | 30.9 |
RSE, relative standard error of model parameter estimates obtained from the NONMEM covariance step; CI, confidence Interval calculated as estimate ± 1.96*RSE; CL/F, apparent total plasma clearance; V/F apparent volume of distribution; Ka: first‐order rate of absorption; θ; NONMEM fixed parameter; ω NONMEM between‐subject random effect; σ NONMEM residual random effect.