Table 6.
5th, 50th, and 95th percentiles of simulated C min and C max after repeated administration of 3 mg/kg/day of propranolol in infants
| Dosing regimen | C min (ng/mL) | C max (ng/mL) |
|---|---|---|
| Regular 12 hour interval | 1.99, 14.0, 39.4 | 24.0, 61.8,131 |
| Administration at clock times 8:00 am and 5:00 pm | 0.803, 11.6, 47.0 | 26.4, 67.1,141 |
| Administration at clock times 8:00 am, 2:00 pm, and 8:00 pm | 1.43, 14.2, 50.2 | 24.7, 62.2, 130 |
| Administration at clock times 8:00 am, 12:00 am and 8:00 pm | 1.53, 15.2, 43.4 | 23.6, 60.1, 128 |