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. 2018 Jan 31;29:13–22. doi: 10.1016/j.ebiom.2018.01.035

Fig. 5.

Fig. 5

Human αSyn expression in the SN leads to reduced striatal DA measured by HPLC. (a) Striatal DA levels. Vector, n = 4, Venus, n = 6, Venus-H, n = 7, 12 weeks post-injection. (b) YFP fluorescence intensity in the SN 4 weeks post-injection. V1SSV2, n = 7, Venus-H, Venus, n = 6. (c–d) Striatal DA levels 4 and 12 weeks post-injection. Venus/4 weeks, n = 7; V1SSV2/4 weeks, n = 8; Venus/12 weeks, n = 6, V1SSV2/12 weeks, n = 12. (e) Striatal DA levels from mice 12 weeks after injection with BiFC vectors (Venus and V1SSV2) and non-BiFC vectors (Vector, αSyn). Venus n = 6, V1SSV2, n = 12; vector, n = 4, αSyn-H, n = 12, αSyn, n = 7. (f) Representative striatal TH immunohistochemistry from a V1SSV2-injected mouse at 12 weeks. Data are expressed as the means ± SEM. #p < 0.05 student t-test, ipsilateral side vs contralateral side. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 ANOVA followed by Tukey's post hoc test.